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Sodium 2-nitro-1,3-dioxopropan-2-ide hydrate; CAS No.: 53821-72-0; Sodium 2-nitro-1,3-dioxopropan-2-ide hydrate. PROPERTIES: This compound is a Sodium 2-nitro-1,3-dioxopropan-2-ide hydrate appearing as white crystalline powder. Its molecular weight is approximately 168.07 g/mol (anhydrous). It has characteristic sharp melting point around 140-145 C (with decomposition). The compound is highly soluble in water and polar organic solvents. It's moisture sensitive and may absorb atmospheric moisture readily. Store in tightly sealed containers under dry conditions. Keep below 25 C and protect from humidity. Handle with care using appropriate engineering controls to prevent dust inhalation. This compound is oxidizing agent and should be stored away from combustible materials. APPLICATIONS: Sodium 2-nitro-1,3-dioxopropan-2-ide hydrate is used in organic synthesis as nitroalkylation reagent as described in Organic Letters. It's employed in preparation of certain antibacterial compounds mentioned in Journal of Medicinal Chemistry. Additionally, this compound serves as building block for preparing nitro-containing pharmaceuticals reported in Bioorganic & Medicinal Chemistry Letters. The nitro group provides valuable electron-withdrawing effect beneficial in receptor binding applications.