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tert-butyl 8-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate
$400.00
CAS No.: 1160247-09-5
Catalog No.: 195837
Purity: 95%
MF: C12H21N3O3
MW: 255.318
Storage: 2-8 degree Celsius
SMILES: O=C1CNC2(CCN(C2)C(=O)OC(C)(C)C)CN1
Catalog No.: 195837
Purity: 95%
MF: C12H21N3O3
MW: 255.318
Storage: 2-8 degree Celsius
SMILES: O=C1CNC2(CCN(C2)C(=O)OC(C)(C)C)CN1
tert-butyl 8-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate; CAS No.: 1160247-09-5; tert-butyl 8-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate. PROPERTIES: tert-butyl 8-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate has molecular formula C11H19N3O3, giving it a molecular weight of 253.30 g/mol. It appears as a white crystalline powder with a melting point between 120-123 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.6 and exhibits moderate aqueous solubility. APPLICATIONS: This tert-butyl 8-oxo-2,6,9-triazaspiro[4.5]decane-2-carboxylate is extensively used in the synthesis of antimicrobial agents. Its triazaspiro-carboxylate-oxo structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The triazaspiro group provides steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The oxo group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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