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4-oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester; CAS No.: 28269-03-6; 4-Oxo-cyclopentane-trans-1,2-dicarboxylic acid dimethyl ester demonstrates our strained carbocyclic diesters for pro-drug development. The trans-diester configuration enables sequential hydrolysis for controlled drug release. ChemShuttle operates as a worldwide chemical supplier of conformationally restricted diacids. Our synthesis employs enzymatic desymmetrization for trans-diester formation. The compound's rigid structure assists in studying enzyme active site flexibility through X-ray crystallography.