trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic acid
$365.00
CAS No.: 671815-99-9
Catalog No.: 195922
Purity: 95%
MF: C14H25NO4
MW: 271.357
Storage: 2-8 degree Celsius
SMILES: C(=O)(OC(C)(C)C)N[C@H](C)[C@@H]1CC[C@H](CC1)C(=O)O
Catalog No.: 195922
Purity: 95%
MF: C14H25NO4
MW: 271.357
Storage: 2-8 degree Celsius
SMILES: C(=O)(OC(C)(C)C)N[C@H](C)[C@@H]1CC[C@H](CC1)C(=O)O
trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic acid; CAS No.: 671815-99-9; trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic acid. PROPERTIES: trans-4-[(R)-1-[(tert-Butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic acid has molecular formula C13H21NNaO4, giving it a molecular weight of 268.32 g/mol. It appears as a white crystalline powder with a melting point between 135-138 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.8 and exhibits moderate aqueous solubility. APPLICATIONS: This trans-4-[(R)-1-[(tert-butyloxycarbonyl)amino]ethyl]cyclohexanecarboxylic acid is extensively used in the synthesis of antimicrobial agents. Its cyclohexane-carboxylic acid-amino structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The Boc-protected amine provides steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The carboxylate group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
Reviews
Write Your Own Review