4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one
$300.00
CAS No.: 863514-54-9
Catalog No.: 195913
Purity: 95%
MF: C14H18FNO
MW: 235.302
Storage: 2-8 degree Celsius
SMILES: CN(C1(CCC(CC1)=O)C1=CC(=CC=C1)F)C
Catalog No.: 195913
Purity: 95%
MF: C14H18FNO
MW: 235.302
Storage: 2-8 degree Celsius
SMILES: CN(C1(CCC(CC1)=O)C1=CC(=CC=C1)F)C
4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one; CAS No.: 863514-54-9; 4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one. PROPERTIES: This compound has molecular formula C16H21FNN2O, giving it a molecular weight of 267.35 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 2.1 and exhibits moderate aqueous solubility. APPLICATIONS: This 4-(dimethylamino)-4-(3-fluorophenyl)cyclohexan-1-one is extensively used in the synthesis of antimicrobial agents. Its cyclohexanone-amino-fluorophenyl structure provides a platform for developing antibacterial agents targeting bacterial DNA gyrase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against Gram-negative pathogens. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The dimethylamino and fluorine substituents provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The ketone group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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