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trans-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid
$300.00
CAS No.: 116823-32-6
Catalog No.: 195569
Purity: 95%
MF: C6H11NO3
MW: 145.158
Storage: 2-8 degree Celsius
SMILES: O=C([C@@]1(N)C[C@H](CO)C1)O
Catalog No.: 195569
Purity: 95%
MF: C6H11NO3
MW: 145.158
Storage: 2-8 degree Celsius
SMILES: O=C([C@@]1(N)C[C@H](CO)C1)O
trans-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid; CAS No.: 116823-32-6; trans-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid. PROPERTIES: trans-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid is a white crystalline powder with molecular formula C6H11NO4. It exhibits a melting point around 175-178 C and moderate thermal stability. The compound shows fair solubility in warm aqueous sodium hydroxide solution and limited solubility in organic solvents. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety precautions involve using acid-resistant gloves during handling to prevent skin irritation from the carboxylic acid group and ensuring proper waste disposal procedures are followed. APPLICATIONS: This amino-substituted cyclobutane derivative serves as a key intermediate in the synthesis of metabotropic glutamate receptor modulators, where the trans-1-amino-3-(hydroxymethyl)cyclobutane-1-carboxylic acid group provides optimal receptor subtype selectivity (Neuropharmacology). In chemical biology, the compound is used as a building block for developing covalent inhibitors targeting protein-protein interaction interfaces (ACS Chemical Biology). Furthermore, its amino and hydroxymethyl groups enable convenient modification for the development of prodrug formulations used in enhanced bioavailability strategies (Journal of Pharmaceutical Sciences).
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