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ethyl 2-(1-aminocyclobutyl)acetate; CAS No.: 1199780-20-5; ethyl 2-(1-aminocyclobutyl)acetate. PROPERTIES: This compound is an ethyl 2-(1-aminocyclobutyl)acetate appearing as colorless liquid. Its molecular weight is approximately 197.25 g/mol. It has characteristic mild odor. The compound is moderately soluble in common organic solvents like ether and chloroform. It's moisture sensitive and may hydrolyze upon exposure to atmospheric moisture. Store in tightly sealed containers under nitrogen atmosphere. Keep below 20 C and protect from moisture. Handle with care using appropriate protective gloves to prevent skin contact. APPLICATIONS: ethyl 2-(1-aminocyclobutyl)acetate is utilized in organic synthesis as aminocyclobutyl building block as detailed in Synthetic Communications. It's employed in preparation of certain beta-blockers with specific stereochemistry mentioned in Journal of Medicinal Chemistry. Additionally, this compound serves as intermediate for synthesizing cyclobutyl-containing pharmaceuticals reported in Bioorganic & Medicinal Chemistry Letters. The ethyl ester group provides valuable site for hydrolysis in prodrug activation mechanisms.