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cyclobutane-1,2-dicarboxylic acid; CAS No.: 3396-14-3; cyclobutane-1,2-dicarboxylic acid. PROPERTIES: Cyclobutane-1,2-dicarboxylic acid is a white crystalline powder with molecular formula C6H8O4. It exhibits a melting point around 205-208 C and demonstrates excellent thermal stability. The compound shows fair solubility in warm aqueous sodium hydroxide solution and limited solubility in common organic solvents. Recommended storage conditions include maintaining temperatures below 30 C in sealed containers. Safety precautions involve using acid-resistant gloves during handling to prevent skin irritation from the carboxylic acid groups and ensuring proper waste disposal procedures are followed. APPLICATIONS: This cyclobutane dicarboxylic acid serves as a key intermediate in the synthesis of biodegradable polyesters used in drug delivery systems, where the cyclobutane-1,2-dicarboxylic acid group provides structural diversity to the polymer backbone (Biomacromolecules). In materials science, the compound is incorporated into polyurethane formulations used in flexible foam applications due to its ability to form flexible urethane linkages (Journal of Applied Polymer Science). Furthermore, its diacid functionality enables formation of various metal-organic frameworks (MOFs) used in gas storage and separation applications (Chemistry of Materials).