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1-(4-methoxyphenyl)cyclobutane carboxylic acid; CAS No.: 50921-37-4; ChemShuttle offers 1-(4-methoxyphenyl)cyclobutane carboxylic acid as a conformationally restricted building block for GPCR targets. The cyclobutane ring introduces strain for enhanced binding entropy compensation, while the methoxy group modulates logP values. Our synthesis employs [2+2] photocycloaddition for stereocontrol.