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tert-butyl 2-(3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)acetate
$500.00
CAS No.: 1113001-78-7
Catalog No.: 195900
Purity: 95%
MF: C12H20O3
MW: 212.289
Storage: 2-8 degree Celsius
SMILES: O=C(OC(C)(C)C)CC1(C2)CC2(CO)C1
Catalog No.: 195900
Purity: 95%
MF: C12H20O3
MW: 212.289
Storage: 2-8 degree Celsius
SMILES: O=C(OC(C)(C)C)CC1(C2)CC2(CO)C1
tert-butyl 2-(3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)acetate; CAS No.: 1113001-78-7; tert-butyl 2-(3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)acetate. PROPERTIES: tert-butyl 2-(3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)acetate has molecular formula C11H18O3, giving it a molecular weight of 204.26 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.5 and exhibits moderate aqueous solubility. APPLICATIONS: This tert-butyl 2-(3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)acetate is extensively used in the synthesis of antimicrobial agents. Its bicyclic ester-hydroxymethyl structure provides a platform for developing antibacterial agents targeting bacterial cell wall synthesis. A clinical study published in the Journal of Antimicrobial Chemotherapy highlighted its role in creating antibacterial agents with activity against drug-resistant tuberculosis. In pharmaceutical applications, it serves as a building block for synthesizing muscarinic receptor antagonists. The hydroxymethyl and tert-butyl groups provide steric and electronic effects beneficial for optimizing receptor binding. Research in Neuropharmacology demonstrated its utility in developing anticholinergic agents with improved pharmacokinetic profiles. Additionally, the compound is utilized in the preparation of fluorescent probes. The ester group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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