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(3-aminobicyclo[1.1.1]pentan-1-yl)methanol
$350.00
CAS No.: 1638767-26-6
Catalog No.: 195880
Purity: 95%
MF: C6H11NO
MW: 113.16
Storage: 2-8 degree Celsius
SMILES: NC12CC(C1)(C2)CO
Catalog No.: 195880
Purity: 95%
MF: C6H11NO
MW: 113.16
Storage: 2-8 degree Celsius
SMILES: NC12CC(C1)(C2)CO
(3-aminobicyclo[1.1.1]pentan-1-yl)methanol; CAS No.: 1638767-26-6; (3-aminobicyclo[1.1.1]pentan-1-yl)methanol. PROPERTIES: (3-Aminobicyclo[1.1.1]pentan-1-yl)methanol has molecular formula C6H12N2O, giving it a molecular weight of 128.17 g/mol. It appears as a white crystalline powder with a melting point between 95-98 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 0.9 and exhibits moderate aqueous solubility. APPLICATIONS: This (3-aminobicyclo[1.1.1]pentan-1-yl)methanol is extensively used in the synthesis of antimicrobial agents. Its bicyclic amine-methanol structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The amine and methanol groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The hydroxyl group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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