DOTAGA-tetra (t-Bu ester)
$500.00
CAS No.: 817562-90-6
Catalog No.: 197776
Purity: 95%
MF: C35H64N4O10
MW: 700.915
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC([C@@H](CCC(=O)O)N1CCN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CC(=O)OC(C)(C)C)=O
Catalog No.: 197776
Purity: 95%
MF: C35H64N4O10
MW: 700.915
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC([C@@H](CCC(=O)O)N1CCN(CCN(CCN(CC1)CC(OC(C)(C)C)=O)CC(OC(C)(C)C)=O)CC(=O)OC(C)(C)C)=O
DOTAGA-tetra (t-Bu ester); (R)-5-(tert-Butoxy)-5-oxo-4-(4,7,10-tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)pentanoic acid; CAS No.: 817562-90-6; DOTAGA-tetra (t-Bu ester). PROPERTIES: DOTAGA-tetra (t-Bu ester) is a macrocyclic chelating agent derivative with molecular formula C36H56N4O12 and molecular weight 764.8 g/mol. It typically exists as a white crystalline powder with limited aqueous solubility, requiring organic solvents like DMSO or DMF for dissolution. The compound is hygroscopic and sensitive to heat, necessitating storage below 0 C in a tightly sealed, desiccated container. Safety considerations include potential irritancy to respiratory tract and skin, requiring careful handling with appropriate personal protective equipment. APPLICATIONS: In radiopharmaceutical chemistry, DOTAGA-tetra (t-Bu ester) functions as a versatile precursor for synthesizing radiolabeled bioconjugates. Upon deprotection, it forms the octadentate DOTAGA chelator, which efficiently coordinates with radiometals like 177Lu and 68Ga for use in targeted radionuclide therapy and PET imaging. This compound is crucial in bioconjugation strategies for attaching radiometals to biomolecules such as antibodies, peptides, and small molecules for cancer targeting and diagnosis. Additionally, it serves as a building block in developing multimodal imaging agents that combine radionuclide imaging with other techniques like fluorescence or MRI. The tetra-tert-butyl ester protects carboxylate groups during synthesis, allowing selective conjugation to biomolecules via amide bond formation or click chemistry approaches before final deprotection and metal complexation. (Radiopharmaceutical chemistry literature and bioconjugation protocols)
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