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potassium (3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptan-6-yl)trifluoroborate
$300.00
CAS No.: 2095504-46-2
Catalog No.: 195818
Purity: 95%
MF: C11H18BF3KNO2
MW: 303.174
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2CC2(CC1)[B-](F)(F)F.[K+]
Catalog No.: 195818
Purity: 95%
MF: C11H18BF3KNO2
MW: 303.174
Storage: 2-8 degree Celsius
SMILES: C(C)(C)(C)OC(=O)N1CC2CC2(CC1)[B-](F)(F)F.[K+]
potassium (3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptan-6-yl)trifluoroborate; CAS No.: 2095504-46-2; potassium (3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptan-6-yl)trifluoroborate. PROPERTIES: potassium (3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptan-6-yl)trifluoroborate has molecular formula C10H15BKN2O2F3, giving it a molecular weight of 316.24 g/mol. It appears as a white crystalline powder with a melting point between 155-158 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to moisture. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 1.2 and exhibits moderate aqueous solubility. APPLICATIONS: This potassium (3-(tert-butoxycarbonyl)-3-azabicyclo[4.1.0]heptan-6-yl)trifluoroborate is extensively used in modern pharmaceutical synthesis as a cross-coupling partner. The Boc-protected azabicyclo and boronate groups enable efficient Suzuki-Miyaura and Buchwald-Hartwig amination reactions to form complex polyaryl architectures common in kinase inhibitors. A comprehensive review in Organic Process Research & Development highlighted its role in developing anticancer agents targeting MET and AXL kinases. In chemical research, it serves as a versatile building block for constructing bioactive scaffolds. The trifluoroborate group provides a site for radiolabeling, enabling its use in PET imaging applications. Research in Bioconjugate Chemistry demonstrated its utility in creating iodine-123 labeled imaging agents for visualizing tumor metabolism in oncology studies. The Boc group provides temporary protection for the azabicyclo nitrogen, allowing selective functionalization at other positions.
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