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5-bromo-1-methyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one
$200.00
CAS No.: 2491753-71-8
Catalog No.: LT0102
Purity: 95%
MF: C13H14BrNO2
MW: 296.164
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=CC1)N(C(C21CCOCC1)=O)C
Catalog No.: LT0102
Purity: 95%
MF: C13H14BrNO2
MW: 296.164
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=CC1)N(C(C21CCOCC1)=O)C
CAS NO.: 2491753-71-8;5-bromo-1-methyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one. PROPERTIES: This brominated spiro-heterocycle presents as a white crystalline solid with a molecular weight of approximately 351.2 g/mol. The 5-bromo-1-methyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one combines a bromine substituent with a spiro-fused indoline and pyran framework. It exhibits limited aqueous solubility but dissolves well in polar aprotic solvents like DMSO and THF. Stability characterization reveals vulnerability to acid-catalyzed spiro-bond cleavage and base-promoted deprotonation of the lactone carbonyl, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 5-bromo-1-methyl-2',3',5',6'-tetrahydrospiro[indoline-3,4'-pyran]-2-one serves as a key intermediate in the synthesis of various pharmaceuticals. Its spiro-fused framework provides opportunities for constructing complex alkaloids and receptor-targeted molecules. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The bromine substituent enhances metabolic resistance in resulting drug candidates. Additionally, it serves as a building block for creating fluorescent probes and bioimaging agents with enhanced photostability.
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