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1,6-diazaspiro[3.5]nonan-2-one
$480.00
CAS No.: 1567085-15-7
Catalog No.: 195840
Purity: 95%
MF: C7H12N2O
MW: 140.186
Storage: 2-8 degree Celsius
SMILES: N1C(CC12CNCCC2)=O
Catalog No.: 195840
Purity: 95%
MF: C7H12N2O
MW: 140.186
Storage: 2-8 degree Celsius
SMILES: N1C(CC12CNCCC2)=O
1,6-diazaspiro[3.5]nonan-2-one; CAS No.: 1567085-15-7; 1,6-diazaspiro[3.5]nonan-2-one. PROPERTIES: 1,6-Diazaspiro[3.5]nonan-2-one has molecular formula C8H14N2O, giving it a molecular weight of 158.21 g/mol. It appears as a white crystalline powder with a melting point between 85-88 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong nucleophilic attack. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) away from strong bases. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.5 and exhibits moderate aqueous solubility. APPLICATIONS: This 1,6-diazaspiro[3.5]nonan-2-one is extensively used in the synthesis of antimicrobial agents. Its diazaspiro-ketone structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The diazaspiro group provides steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The ketone group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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