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3-azaspiro[5.5]undecane-2,4-dione
$300.00
CAS No.: 1130-32-1
Catalog No.: 196736
Purity: 95%
MF: C10H15NO2
MW: 181.235
Storage: 2-8 degree Celsius
SMILES: C1C(NC(CC12CCCCC2)=O)=O
Catalog No.: 196736
Purity: 95%
MF: C10H15NO2
MW: 181.235
Storage: 2-8 degree Celsius
SMILES: C1C(NC(CC12CCCCC2)=O)=O
3-azaspiro[5.5]undecane-2,4-dione; CAS No.: 1130-32-1; 3-azaspiro[5.5]undecane-2,4-dione. PROPERTIES: This azaspiro compound features molecular formula C??H??NO? with molecular weight 183.25 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 140-145 C. Exhibits IR absorption for amide (~1650 cm??) and ketone groups (~1700 cm??). Thermogravimetric analysis reveals weight loss onset above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a spirocyclic compound, 3-azaspiro[5.5]undecane-2,4-dione is predominantly utilized in the synthesis of nonsteroidal anti-inflammatory drugs (NSAIDs). It serves as a key intermediate in constructing coxib-class COX-2 inhibitors, where the spirocyclic structure provides valuable conformational constraints for selective enzyme inhibition as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its spirocyclic framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the spirocyclic group contributes to improved flame retardancy and mechanical properties (Polymer International).
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