1-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride
$250.00
CAS No.: 1363404-80-1
Catalog No.: 192849
Purity: 95%
MF: C7H16ClNO
MW: 165.664
Storage: 2-8 degree Celsius
SMILES: Cl.O1CCC(CC1)C(C)N
Catalog No.: 192849
Purity: 95%
MF: C7H16ClNO
MW: 165.664
Storage: 2-8 degree Celsius
SMILES: Cl.O1CCC(CC1)C(C)N
1-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride; CAS No.: 1363404-80-1; 1-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride. PROPERTIES: This tetrahydropyran-substituted ethanamine salt has molecular formula C8H16N2O {HCl. It appears as a white crystalline powder. The 1-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride exhibits high water solubility (exceeding 100 mg/mL) and moderate solubility in common polar solvents. Its melting point ranges between 180-185 C (with decomposition), and it has a molecular weight of approximately 184.68 g/mol (free base). When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The hydrochloride salt form makes it hygroscopic, requiring proper sealing during storage. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 1-(tetrahydro-2H-pyran-4-yl)ethanamine hydrochloride serves as a key intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the tetrahydropyran ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The ethanamine group forms additional hydrogen bonds with receptor residues. Additionally, the compound functions as a building block in the preparation of bioconjugates for drug delivery systems where the amine group reacts with targeting moieties, as described in pharmaceutical sciences journals. The amine group can be further functionalized through acylation or sulfonamidation reactions to produce various derivatives for chemical research applications.
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