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(((1-(6-amino-9H-purin-9-yl)propan-2-yl)oxy)methyl)phosphonic acid; CAS No.: 147127-20-6; This phosphonic acid adenine conjugate represents ChemShuttle s key intermediates for nucleotide therapeutics. The propan-2-yloxy linker and phosphonate group mimic pyrophosphate moieties in antiviral prodrugs. Our synthesis employs H-phosphonate coupling followed by oxidation, achieving high purity for enzymatic phosphorylation studies. The product supports research into hepatitis B polymerase inhibitors and exonuclease-resistant oligonucleotides.