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bicyclo[2.2.2]octane-1,4-diol
$450.00
CAS No.: 1194-44-1
Catalog No.: 195883
Purity: 95%
MF: C8H14O2
MW: 142.198
Storage: 2-8 degree Celsius
SMILES: C12(CCC(CC1)(CC2)O)O
Catalog No.: 195883
Purity: 95%
MF: C8H14O2
MW: 142.198
Storage: 2-8 degree Celsius
SMILES: C12(CCC(CC1)(CC2)O)O
bicyclo[2.2.2]octane-1,4-diol; CAS No.: 1194-44-1; bicyclo[2.2.2]octane-1,4-diol. PROPERTIES: Bicyclo[2.2.2]octane-1,4-diol has molecular formula C8H12O2, giving it a molecular weight of 152.18 g/mol. It appears as a white crystalline powder with a melting point between 100-103 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 75 C. The compound has a logP value of approximately 1.2 and exhibits moderate aqueous solubility. APPLICATIONS: This bicyclo[2.2.2]octane-1,4-diol is extensively used in the synthesis of antimicrobial agents. Its bicyclic diol structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The diol groups provide hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The diol groups provide sites for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Dyes and Pigments.
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