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AG 1478; N-(3-chlorophenyl)-6,7-dimethoxyquinazolin-4-amine; CAS No.: 153436-53-4; As a worldwide chemical supplier, ChemShuttle provides chlorophenyl quinazolinamines for EGFR tyrosine kinase inhibition. The 6,7-dimethoxy groups enhance water solubility while maintaining ATP-binding affinity. Our Gould-Jacobs cyclization achieves high-purity quinazoline ring formation. This intermediate supports development of fourth-generation TKIs targeting resistant mutations.