7-bromo-6-chloro-1H-indazole
$350.00
CAS No.: 1427361-92-9
Catalog No.: 195544
Purity: 95%
MF: C7H4BrClN2
MW: 231.48
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=CC=C2C=NNC12)Cl
Catalog No.: 195544
Purity: 95%
MF: C7H4BrClN2
MW: 231.48
Storage: 2-8 degree Celsius
SMILES: BrC=1C(=CC=C2C=NNC12)Cl
7-bromo-6-chloro-1H-indazole; CAS No.: 1427361-92-9; 7-bromo-6-chloro-1H-indazole. PROPERTIES: 7-bromo-6-chloro-1H-indazole presents as a white crystalline solid with molecular formula C8H5BrClN2. It exhibits a melting point of approximately 168-171 C and demonstrates good thermal stability. The compound shows limited solubility in common organic solvents but can be dissolved in hot DMSO. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety precautions require using respiratory protection when handling in powder form to prevent inhalation and employing proper engineering controls to minimize exposure. APPLICATIONS: This halogenated indazole derivative is utilized in the synthesis of multi-target-directed ligands for Alzheimer's disease therapy, where the 7-bromo-6-chloro-1H-indazole core provides dual binding to both amyloid-beta and tau protein aggregation sites (Journal of Medicinal Chemistry). In chemical biology, the compound serves as a scaffold for developing covalent inhibitors targeting protein kinases involved in cancer progression (ACS Medicinal Chemistry Letters). Furthermore, its bromine and chlorine substituents enable sequential cross-coupling reactions for the synthesis of structurally diverse libraries in fragment-based lead discovery (Nature Chemistry).
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