6-(trifluoromethyl)indoline
$300.00
CAS No.: 181513-29-1
Catalog No.: 196232
Purity: 95%
MF: C9H8F3N
MW: 187.164
Storage: 2-8 degree Celsius
SMILES: FC(C1=CC=C2CCNC2=C1)(F)F
Catalog No.: 196232
Purity: 95%
MF: C9H8F3N
MW: 187.164
Storage: 2-8 degree Celsius
SMILES: FC(C1=CC=C2CCNC2=C1)(F)F
6-(trifluoromethyl)indoline; CAS No.: 181513-29-1; 6-(trifluoromethyl)indoline. PROPERTIES: This compound features a 6-(trifluoromethyl)indoline structure, combining a trifluoromethyl group and an indoline framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 198.1 g/mol (C9H8F3N). The melting point ranges between 70-75 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 6-(Trifluoromethyl)indoline serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 6-(trifluoromethyl)indoline structure enables diverse reactivity patterns, including electrophilic substitution at the indoline ring and nucleophilic substitution at the trifluoromethyl group. In medicinal chemistry, it is used to develop bioactive molecules targeting the central nervous system and inflammatory pathways. The trifluoromethyl group provides metabolic stability and favorable binding interactions with biological targets. This compound also functions as a building block in the synthesis of agrochemicals (though agricultural applications are excluded here). Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel trifluoromethylindoline derivatives based on the 6-(trifluoromethyl)indoline scaffold.
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