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6-bromo-2-methyloxazolo[4,5-b]pyridine
$300.00
CAS No.: 494747-09-0
Catalog No.: 196120
Purity: 95%
MF: C7H5BrN2O
MW: 213.034
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC1)N=C(O2)C
Catalog No.: 196120
Purity: 95%
MF: C7H5BrN2O
MW: 213.034
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C2C(=NC1)N=C(O2)C
6-bromo-2-methyloxazolo[4,5-b]pyridine; CAS No.: 494747-09-0; 6-bromo-2-methyloxazolo[4,5-b]pyridine. PROPERTIES: This white to off-white solid has a molecular formula of C8H5BrN2O and a molecular weight of approximately 225.05 g/mol. It exhibits moderate solubility in DMSO and DMF but is sparingly soluble in water. The compound is light-sensitive and should be stored in a tightly sealed container at 2-8 C, protected from light. Thermogravimetric analysis shows decomposition starting at 230 C. Safety precautions include using chemical-resistant gloves, safety goggles, and working in a well-ventilated area. In case of accidental ingestion, do not induce vomiting and seek immediate medical advice. Avoid release to the environment as brominated heterocycles may persist and bioaccumulate. APPLICATIONS: 6-bromo-2-methyloxazolo[4,5-b]pyridine functions as a valuable intermediate in the synthesis of bioactive compounds. Its bromine substituent enables Suzuki coupling reactions for diversifying substituent patterns. The oxazolopyridine core has demonstrated utility in developing antiviral agents targeting RNA-dependent RNA polymerases. Research groups employ it in fragment-based approaches to discover novel inhibitors of epigenetic targets. The methyl group at position 2 provides steric hindrance useful in modulating protein-ligand interactions. Academic institutions utilize it in teaching synthetic methodologies involving heterocyclic chemistry. Industrial applications include its use as a building block in agrochemical development for herbicide and insecticide candidates. Recent studies in the Journal of Heterocyclic Chemistry highlight its application in multicomponent reactions for rapid library generation. Additionally, it serves as a starting material for radiolabeled compounds used in PET imaging studies.
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