5-propyl-1,8-naphthyridin-2(1H)-one
$400.00
CAS No.: 2703752-20-7
Catalog No.: 192758
Purity: 95%
MF: C11H12N2O
MW: 188.23
Storage: 2-8 degree Celsius
SMILES: C(CC)C1=C2C=CC(NC2=NC=C1)=O
Catalog No.: 192758
Purity: 95%
MF: C11H12N2O
MW: 188.23
Storage: 2-8 degree Celsius
SMILES: C(CC)C1=C2C=CC(NC2=NC=C1)=O
5-propyl-1,8-naphthyridin-2(1H)-one; CAS No.: 2703752-20-7; 5-propyl-1,8-naphthyridin-2(1H)-one. PROPERTIES: This propyl-substituted naphthyridinone has molecular formula C12H12N2O. It generally appears as a white crystalline powder. The 5-propyl-1,8-naphthyridin-2(1H)-one demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 140-145 C, and it has a molecular weight of approximately 196.24 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may decompose upon exposure to high temperatures above 180 C. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-propyl-1,8-naphthyridin-2(1H)-one serves as a valuable intermediate in the synthesis of dual orexin receptor antagonists for insomnia treatment where the naphthyridinone ring provides essential hydrogen bonding interactions with receptor subtypes (as detailed in medicinal chemistry literature). The propyl group enhances metabolic stability by preventing oxidative degradation. Additionally, the compound functions as a building block in the preparation of fluorescent dyes for bioimaging applications with excitation maxima around 360 nm and emission maxima around 430 nm, as described in bioanalytical chemistry journals. The ketone group can be further functionalized through reduction or alkylation reactions to produce various derivatives for chemical research applications.
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