5-iodo-N,N,2-trimethylbenzamide
$360.00
CAS No.: 1228778-17-3
Catalog No.: 197082
Purity: 95%
MF: C10H12INO
MW: 289.116
Storage: 2-8 degree Celsius
SMILES: IC=1C=CC(=C(C(=O)N(C)C)C1)C
Catalog No.: 197082
Purity: 95%
MF: C10H12INO
MW: 289.116
Storage: 2-8 degree Celsius
SMILES: IC=1C=CC(=C(C(=O)N(C)C)C1)C
5-iodo-N,N,2-trimethylbenzamide; CAS No.: 1228778-17-3; 5-iodo-N,N,2-trimethylbenzamide. PROPERTIES: This iodo-methyl-substituted benzamide features molecular formula C?H?INO with molecular weight 278.09 g/mol. It generally appears as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 100-105 C. Exhibits IR absorption for amide (~1650 cm??) and C-I groups (~550-450 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As an iodo-methyl-substituted benzamide, 5-iodo-N,N,2-trimethylbenzamide is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the iod substituent provides valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its amide functionality enables conjugation to biomolecules via reductive amination (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the iod substituent contributes to improved flame retardancy and mechanical properties (Polymer International).
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