5-bromo-2-methyl-2H-indazole-3-carboxylic acid
$300.00
CAS No.: 1534688-50-0
Catalog No.: 195542
Purity: 95%
MF: C9H7BrN2O2
MW: 255.071
Storage: 2-8 degree Celsius
SMILES: BrC1=CC2=C(N(N=C2C=C1)C)C(=O)O
Catalog No.: 195542
Purity: 95%
MF: C9H7BrN2O2
MW: 255.071
Storage: 2-8 degree Celsius
SMILES: BrC1=CC2=C(N(N=C2C=C1)C)C(=O)O
5-bromo-2-methyl-2H-indazole-3-carboxylic acid; CAS No.: 1534688-50-0; 5-bromo-2-methyl-2H-indazole-3-carboxylic acid. PROPERTIES: 5-bromo-2-methyl-2H-indazole-3-carboxylic acid is a white crystalline powder with molecular formula C10H7BrN3O2. It exhibits a melting point of approximately 205-208 C and shows good thermal stability. The compound demonstrates fair solubility in warm aqueous sodium hydroxide solution and limited solubility in organic solvents. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety precautions involve using acid-resistant gloves during handling to prevent skin irritation from the carboxylic acid group and ensuring proper waste disposal procedures are followed. APPLICATIONS: This brominated indazole carboxylic acid serves as a key intermediate in the synthesis of VEGFR inhibitors for angiogenesis modulation in cancer therapy, where the 5-bromo-2-methyl-2H-indazole-3-carboxylic acid group contributes to receptor tyrosine kinase inhibition (Molecular Cancer Therapeutics). In bioorganic chemistry, the compound is used as a building block for developing peptidomimetic inhibitors targeting matrix metalloproteinases (Journal of Biological Chemistry). Additionally, its acidic functionality enables formation of bioactive metal complexes used in photodynamic therapy applications (Photochemistry and Photobiology).
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