5-bromo-1H-indazol-4-amine
$300.00
CAS No.: 1891120-48-1
Catalog No.: 192658
Purity: 95%
MF: C7H6BrN3
MW: 212.05
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=2C=NNC2C=C1)N
Catalog No.: 192658
Purity: 95%
MF: C7H6BrN3
MW: 212.05
Storage: 2-8 degree Celsius
SMILES: BrC1=C(C=2C=NNC2C=C1)N
5-bromo-1H-indazol-4-amine; CAS No.: 1891120-48-1; 5-bromo-1H-indazol-4-amine. PROPERTIES: This brominated indazole amine has molecular formula C7H6BrN3. It typically appears as a white to slightly yellow crystalline solid. The 5-bromo-1H-indazol-4-amine demonstrates limited water solubility but good solubility in DMSO and DMF. Its melting point ranges between 175-178 C, and it has a molecular weight of approximately 212.05 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong oxidizing agents and may form explosive products upon exposure to heat or shock. In case of eye contact, immediate rinsing with water for 15 minutes is necessary. APPLICATIONS: The 5-bromo-1H-indazol-4-amine functions as a valuable intermediate in the synthesis of VEGFR inhibitors for cancer therapy where the bromine atom provides essential binding interactions with kinase residues (as reported in medicinal chemistry literature). The amine group provides hydrogen bonding capabilities important for enzyme inhibition. Additionally, the compound serves as a building block in the preparation of agrochemicals with insecticidal activity, though this application is mentioned only for informational purposes per your request. The bromine atom can be replaced with various substituents through Suzuki-Miyaura coupling reactions to produce diverse derivatives for chemical research applications.
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