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5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine
$200.00
CAS No.: 771510-32-8
Catalog No.: 195654
Purity: 95%
MF: C9H9Cl2N3
MW: 230.098
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=2N(C(=C1)Cl)N=CC2C(C)C
Catalog No.: 195654
Purity: 95%
MF: C9H9Cl2N3
MW: 230.098
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=2N(C(=C1)Cl)N=CC2C(C)C
5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine; CAS No.: 771510-32-8; 5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine. PROPERTIES: 5,7-Dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine has molecular formula C10H10Cl2N4, corresponding to a molecular weight of 261.12 g/mol. It appears as a white crystalline solid with a melting point between 190-193 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong nucleophilic attack. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause skin irritation and has a flash point of approximately 105 C. The compound has a logP value of approximately 1.9 and exhibits limited aqueous solubility. APPLICATIONS: This 5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine is extensively used in the synthesis of anticancer agents. Its dichlorinated pyrazolopyrimidine structure provides a novel scaffold for developing kinase inhibitors targeting wild-type and mutant BCR-ABL kinases. A clinical trial reported in Cancer Research highlighted its role in developing therapies for imatinib-resistant chronic myeloid leukemia. In agrochemical applications, it serves as a building block for synthesizing herbicides with novel modes of action. The chloro substituents enhance binding to plant enzyme active sites, providing selective herbicidal activity. Research in Pest Management Science demonstrated its utility in creating herbicides targeting acetolactate synthase (ALS) inhibition. Additionally, the compound is utilized in the preparation of pyrazolopyrimidine-containing antiviral agents. The isopropyl group provides steric effects beneficial for optimizing binding to viral polymerase active sites, as reported in Antiviral Research.
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