5-(4-methoxyphenyl)pyrimidin-2-amine
$360.00
CAS No.: 31408-47-6
Catalog No.: 196432
Purity: 95%
MF: C11H11N3O
MW: 201.229
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(C=C1)C=1C=NC(=NC1)N
Catalog No.: 196432
Purity: 95%
MF: C11H11N3O
MW: 201.229
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C(C=C1)C=1C=NC(=NC1)N
5-(4-methoxyphenyl)pyrimidin-2-amine; CAS No.: 31408-47-6; 5-(4-methoxyphenyl)pyrimidin-2-amine. PROPERTIES: This compound features a 5-(4-methoxyphenyl)pyrimidin-2-amine structure, combining a methoxyphenyl group and an amine substituent on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 213.2 g/mol (C11H11N3O). The melting point ranges between 130-135 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 5-(4-Methoxyphenyl)pyrimidin-2-amine serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 5-(4-methoxyphenyl)pyrimidin-2-amine structure allows for participation in various reactions, including nucleophilic substitution at the pyrimidine ring and hydrogen bonding interactions through the amino group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The methoxyphenyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Medicinal Chemistry journals, focusing on optimizing the 5-(4-methoxyphenyl)pyrimidin-2-amine scaffold for improved biological activity and pharmacokinetic properties.
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