4-(trifluoromethyl)pyrimidine-5-carboxamide
$300.00
CAS No.: 2639626-83-6
Catalog No.: 192966
Purity: 95%
MF: C6H4F3N3O
MW: 191.112
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=NC=C1C(=O)N)(F)F
Catalog No.: 192966
Purity: 95%
MF: C6H4F3N3O
MW: 191.112
Storage: 2-8 degree Celsius
SMILES: FC(C1=NC=NC=C1C(=O)N)(F)F
4-(trifluoromethyl)pyrimidine-5-carboxamide; CAS No.: 2639626-83-6; 4-(trifluoromethyl)pyrimidine-5-carboxamide. PROPERTIES: This compound presents as a white crystalline solid with molecular formula C6H4F3N3O and a molecular weight of 205.11 g/mol. It demonstrates a melting point in the range of 152-156 C and shows moderate solubility in common organic solvents like dichloromethane and acetone. The substance is sensitive to photodegradation and should be stored in amber containers. Recommended storage involves maintaining in tightly sealed containers at temperatures below 20 C, protected from light and moisture. When handling, standard laboratory safety protocols should be followed, including the use of protective gloves and eye wear, as 4-(trifluoromethyl)pyrimidine-5-carboxamide may release toxic fumes upon heating. The trifluoromethyl group requires careful handling in strongly basic environments. APPLICATIONS: In medicinal chemistry, 4-(trifluoromethyl)pyrimidine-5-carboxamide serves as a key intermediate for synthesizing anticancer agents, as documented in pharmaceutical research focusing on kinase inhibitors. Its trifluoromethyl substituent enables improved metabolic stability in biological systems. Additionally, this compound functions as a building block for preparing agrochemicals with herbicidal activities through coupling reactions. Academic studies have explored its potential in the development of fluorescent probes for bioimaging applications, as reported in biochemical journals. The pyrimidine ring system also facilitates coordination with metal ions, making it valuable for creating luminescent materials in materials science applications, as evidenced by inorganic chemistry publications.
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