4-iodoisoquinoline
$400.00
CAS No.: 55270-33-2
Catalog No.: 196248
Purity: 95%
MF: C9H6IN
MW: 255.058
Storage: 2-8 degree Celsius
SMILES: IC1=CN=CC2=CC=CC=C12
Catalog No.: 196248
Purity: 95%
MF: C9H6IN
MW: 255.058
Storage: 2-8 degree Celsius
SMILES: IC1=CN=CC2=CC=CC=C12
4-iodoisoquinoline; CAS No.: 55270-33-2; 4-iodoisoquinoline. PROPERTIES: This compound features a 4-iodoisoquinoline structure, combining an iodine atom and an isoquinoline framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 240.1 g/mol (C8H5IN). The melting point ranges between 140-145 C, and it exhibits moderate solubility in common organic solvents like DMSO and DMF while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Iodoisoquinoline serves as a versatile intermediate in pharmaceutical and chemical synthesis. Its 4-iodoisoquinoline structure allows for participation in various reactions, including palladium-catalyzed cross-coupling reactions at the iodine position and electrophilic substitution at the isoquinoline ring. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The iodine atom provides a highly reactive handle for introducing aryl, vinyl, or heterocyclic substituents. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies employ it as a model compound in Organic Chemistry journals, focusing on the development of novel iodoisoquinoline derivatives based on the 4-iodoisoquinoline scaffold.
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