4-(chloromethyl)benzophenone
$200.00
CAS No.: 42728-62-1
Catalog No.: 194025
Purity: 95%
MF: C14H11ClO
MW: 230.694
Storage: 2-8 degree Celsius
SMILES: ClCC1=CC=C(C(=O)C2=CC=CC=C2)C=C1
Catalog No.: 194025
Purity: 95%
MF: C14H11ClO
MW: 230.694
Storage: 2-8 degree Celsius
SMILES: ClCC1=CC=C(C(=O)C2=CC=CC=C2)C=C1
4-(chloromethyl)benzophenone; CAS No.: 42728-62-1; 4-(chloromethyl)benzophenone. PROPERTIES: 4-(chloromethyl)benzophenone is an aromatic ketone with a chloromethyl substituent, having a molecular weight of approximately 222.6 g/mol. It typically appears as a colorless to pale yellow liquid with a characteristic ketone odor. The substance has a boiling point in the range of 150-155 C and a density of approximately 1.15 g/cm?. It exhibits moderate solubility in organic solvents such as methanol, acetone, and hexane, but is sparingly soluble in water. Proper storage requires a cool, dry location in tightly sealed containers. Safety precautions include classification as harmful if swallowed, causes skin irritation, and may cause eye irritation. Standard laboratory PPE is recommended. Occupational exposure follows general OSHA guidelines for chlorinated ketones. APPLICATIONS: 4-(chloromethyl)benzophenone serves as a versatile electrophile in the synthesis of beta-blockers, where the chloromethyl group reacts with amines to form crucial amine linkages. The benzophenone structure provides optimal electronic effects for enzyme binding. In materials science, the compound is utilized in the preparation of photostabilizers for polymers, with the ketone group absorbing UV radiation and the chloromethyl group enabling covalent attachment to polymer backbones. The Journal of Organic Chemistry frequently reports on similar chloromethyl ketones in macromolecular synthesis. Additionally, 4-(chloromethyl)benzophenone functions as a building block in the synthesis of agrochemical intermediates, though this application is outside the specified scope. The compound's reactivity allows for nucleophilic substitution reactions at the chloromethyl position, enabling the formation of various secondary metabolites with potential pharmaceutical applications. Recent advances in cross-coupling chemistry have expanded the utility of this benzophenone derivative in forming carbon-carbon bonds for the synthesis of complex aromatic architectures.
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