4-chloro-6-trifluoromethylpyrimidine
$300.00
CAS No.: 37552-81-1
Catalog No.: 197028
Purity: 95%
MF: C5H2ClF3N2
MW: 182.532
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1)C(F)(F)F
Catalog No.: 197028
Purity: 95%
MF: C5H2ClF3N2
MW: 182.532
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1)C(F)(F)F
4-chloro-6-trifluoromethylpyrimidine; CAS No.: 37552-81-1; 4-chloro-6-trifluoromethylpyrimidine. PROPERTIES: This chloro-trifluoromethyl-substituted pyrimidine features molecular formula C?H?ClF?N? with molecular weight 177.51 g/mol. It typically exists as a white crystalline powder. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Melting point approximately 60-65 C. Exhibits IR absorption for C-Cl (~600-500 cm??) and C-F stretches (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a chloro-trifluoromethyl-substituted pyrimidine, 4-chloro-6-trifluoromethylpyrimidine is predominantly utilized in the synthesis of agrochemicals. It serves as a key intermediate in constructing pyrimidine-based herbicides, where the chloro and trifluoromethyl groups provide valuable binding affinity for plant enzymes as demonstrated in pesticide chemistry research (Pest Management Science). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its pyrimidine framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the trifluoromethyl group contributes to improved flame retardancy and mechanical properties (Polymer International).
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