4-chloro-6-phenoxypyrimidine
$300.00
CAS No.: 124041-00-5
Catalog No.: 196429
Purity: 95%
MF: C10H7ClN2O
MW: 206.632
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1)OC1=CC=CC=C1
Catalog No.: 196429
Purity: 95%
MF: C10H7ClN2O
MW: 206.632
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC(=C1)OC1=CC=CC=C1
4-chloro-6-phenoxypyrimidine; CAS No.: 124041-00-5; 4-chloro-6-phenoxypyrimidine. PROPERTIES: This compound presents a 4-chloro-6-phenoxypyrimidine structure, combining a chloro substituent and a phenoxyl group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 201.1 g/mol (C9H6ClN2O). The melting point ranges between 120-125 C, and it exhibits moderate solubility in common organic solvents like ethyl acetate, dichloromethane, and tetrahydrofuran while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Chloro-6-phenoxypyrimidine serves as a specialized intermediate in pharmaceutical research. Its 4-chloro-6-phenoxypyrimidine structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro position and hydrogen bonding interactions through the phenoxyl group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The phenoxyl group provides additional conjugation that enhances binding to biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-chloro-6-phenoxypyrimidine scaffold for improved biological activity and pharmacokinetic properties.
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