4-chloro-6-ethoxypyrimidin-2-amine
$350.00
CAS No.: 89784-02-1
Catalog No.: 196427
Purity: 95%
MF: C6H8ClN3O
MW: 173.603
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)OCC)N
Catalog No.: 196427
Purity: 95%
MF: C6H8ClN3O
MW: 173.603
Storage: 2-8 degree Celsius
SMILES: ClC1=NC(=NC(=C1)OCC)N
4-chloro-6-ethoxypyrimidin-2-amine; CAS No.: 89784-02-1; 4-chloro-6-ethoxypyrimidin-2-amine. PROPERTIES: This compound presents a 4-chloro-6-ethoxypyrimidin-2-amine structure, combining a chloro substituent, an ethoxy group, and an amine group on the pyrimidine framework. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 183.1 g/mol (C6H8ClN3O). The melting point ranges between 90-95 C, and it exhibits moderate solubility in common organic solvents like ethanol, methanol, and DMSO while being sparingly soluble in water. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-Chloro-6-ethoxypyrimidin-2-amine serves as a specialized intermediate in pharmaceutical research. Its 4-chloro-6-ethoxypyrimidin-2-amine structure enables diverse reactivity patterns, including nucleophilic substitution at the chloro position and hydrogen bonding interactions through the amino group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The ethoxy group provides steric and electronic effects that influence binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-chloro-6-ethoxypyrimidin-2-amine scaffold for improved biological activity and target engagement.
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