4-chloro-6,7-difluoroquinazoline
$450.00
CAS No.: 625080-60-6
Catalog No.: 196012
Purity: 95%
MF: C8H3ClF2N2
MW: 200.575
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=C(C=C12)F)F
Catalog No.: 196012
Purity: 95%
MF: C8H3ClF2N2
MW: 200.575
Storage: 2-8 degree Celsius
SMILES: ClC1=NC=NC2=CC(=C(C=C12)F)F
4-chloro-6,7-difluoroquinazoline; CAS No.: 625080-60-6; 4-chloro-6,7-difluoroquinazoline. PROPERTIES: 4-chloro-6,7-difluoroquinazoline is a crystalline solid with molecular formula C8H3ClF2N2, having a molar mass of approximately 202.58 g/mol. It shows limited water solubility but satisfactory solubility in acetonitrile and tetrahydrofuran. Melting point determinations typically yield values between 135-139 C. Proper storage necessitates airtight containers with desiccant, maintained at temperatures below 25 C and shielded from light. Safety precautions highlight potential for causing skin irritation and serious eye damage, mandating protective eyewear and gloves during handling. In case of accidental ingestion, immediate medical attention is required. APPLICATIONS: This chlorofluorinated quinazoline derivative is pivotal in oncology drug development, particularly as an intermediate for epidermal growth factor receptor (EGFR) inhibitors. Its halogen substitution pattern enables selective tyrosine kinase inhibition. In agrochemical research (non-agricultural context), it contributes to safener compound synthesis that protect crops without direct agricultural application. Additionally, the compound supports materials science applications in fluorinated polymer development, with methodologies published in medicinal chemistry journals and patent literature, illustrating its cross-disciplinary utility in pharmaceutical and materials innovation.
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