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CAS NO.: 351003-50-4; 4-Bromo-2,6-dimethylbenzene-1-sulfonyl chloride. PROPERTIES: This sulfonyl chloride is a solid with a melting point of ~68 C70 C. It is sensitive to moisture, hydrolyzing to the corresponding sulfonic acid, so store in a sealed, anhydrous container. It is soluble in dichloromethane or toluene. As a sulfonyl chloride, it is highly reactive and corrosive, causing severe skin and eye irritation wear full protective gear and work in a fume hood. APPLICATIONS: In organic synthesis, this reagent is used for sulfonylation reactions to form sulfonamides or sulfonic esters. The bromo and methyl groups on the benzene ring allow for further functionalization, such as nucleophilic substitution or metal-catalyzed cross-coupling. It is used in synthesizing pharmaceuticals, agrochemicals, and materials like sulfonamide-based polymers. This application aligns with sulfonylation methodologies in organic chemistry and industrial synthetic processes.