4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride
$200.00
CAS No.: 287952-09-4
Catalog No.: 196320
Purity: 95%
MF: C12H15ClF3NO
MW: 281.705
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1=CC=C(OC2CCNCC2)C=C1)(F)F
Catalog No.: 196320
Purity: 95%
MF: C12H15ClF3NO
MW: 281.705
Storage: 2-8 degree Celsius
SMILES: Cl.FC(C1=CC=C(OC2CCNCC2)C=C1)(F)F
4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride; CAS No.: 287952-09-4; 4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride. PROPERTIES: This compound presents a 4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride structure, combining a trifluoromethylphenoxy group and a piperidine ring, and presented as a hydrochloride salt. It typically appears as a white to off-white crystalline solid with a molecular weight of approximately 252.2 g/mol (C12H15F3N {HCl). The melting point ranges between 120-125 C, and it exhibits good solubility in water and common organic solvents like ethanol and methanol. Proper storage requires a tightly sealed container in a cool, dry place. Safety considerations include wearing appropriate PPE. It is classified as a skin and eye irritant (GHS07) with the hazard statement H315-H319. APPLICATIONS: 4-(4-(Trifluoromethyl)phenoxy)piperidine hydrochloride serves as a specialized intermediate in pharmaceutical research. Its 4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride structure enables diverse reactivity patterns, including nucleophilic substitution at the piperidine nitrogen and hydrogen bonding interactions through the phenoxy group. In medicinal chemistry, it is used to develop bioactive molecules targeting kinases, proteases, and G protein-coupled receptors. The trifluoromethyl group provides metabolic stability and favorable binding interactions with biological targets. This compound also functions as a building block in the synthesis of fluorescent dyes and bioconjugation reagents. Academic studies utilize it as a model system in Medicinal Chemistry journals, focusing on optimizing the 4-(4-(trifluoromethyl)phenoxy)piperidine hydrochloride scaffold for improved biological activity and target engagement.
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