3-fluoro-2-iodotoluene
$300.00
CAS No.: 883502-14-5
Catalog No.: 197118
Purity: 95%
MF: C7H6FI
MW: 236.027
Storage: 2-8 degree Celsius
SMILES: FC=1C(=C(C)C=CC1)I
Catalog No.: 197118
Purity: 95%
MF: C7H6FI
MW: 236.027
Storage: 2-8 degree Celsius
SMILES: FC=1C(=C(C)C=CC1)I
3-fluoro-2-iodotoluene; CAS No.: 883502-14-5; 3-fluoro-2-iodotoluene. PROPERTIES: This fluoro-iodo-substituted toluene features molecular formula C?H?FIO with molecular weight 228.03 g/mol. It generally appears as a colorless liquid. Soluble in non-polar and slightly polar organic solvents like hexanes and ethyl acetate. Boiling point approximately 150-155 C. Exhibits IR absorption for C-F (~1300-1100 cm??) and C-I groups (~550-450 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause severe skin burns and eye damage; therefore, rigorous containment and personal protection measures are essential during manipulation. APPLICATIONS: As a fluoro-iodo-substituted toluene, 3-fluoro-2-iodotoluene is predominantly utilized in the synthesis of biaryl-containing pharmaceuticals. It serves as a key intermediate in constructing biaryl scaffolds through Suzuki-Miyaura coupling reactions, where the iodo and fluoro substituents provide valuable sites for cross-coupling as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its toluene framework enables conjugation to fluorophores with enhanced photostability (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyaryl ethers with enhanced flame retardancy, where the fluoro and iodo substituents contribute to improved fire-resistant characteristics (Polymer International).
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