3-bromo-1-hydroxynaphthalene
$250.00
CAS No.: 90767-17-2
Catalog No.: 195800
Purity: 95%
MF: C10H7BrO
MW: 223.069
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C(C2=CC=CC=C2C1)O
Catalog No.: 195800
Purity: 95%
MF: C10H7BrO
MW: 223.069
Storage: 2-8 degree Celsius
SMILES: BrC=1C=C(C2=CC=CC=C2C1)O
3-bromo-1-hydroxynaphthalene; CAS No.: 90767-17-2; 3-bromo-1-hydroxynaphthalene. PROPERTIES: 3-Bromo-1-hydroxynaphthalene has molecular formula C10H7BrO, giving it a molecular weight of 235.08 g/mol. It appears as a white crystalline powder with a melting point between 75-78 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 2.5 and exhibits moderate aqueous solubility. APPLICATIONS: This 3-bromo-1-hydroxynaphthalene is extensively used in the synthesis of antimicrobial agents. Its naphthol-bromo structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The bromo and hydroxyl groups provide steric and electronic effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent dyes. The hydroxyl group provides a site for installing fluorescence-enhancing moieties, enabling detection of nucleic acid hybridization events, as reported in Chemical Communications.
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