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3,6-dibromopyrazolo[1,5-a]pyrimidine
$200.00
CAS No.: 55405-68-0
Catalog No.: 192053
Purity: 95%
MF: C6H3Br2N3
MW: 276.919
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)Br
Catalog No.: 192053
Purity: 95%
MF: C6H3Br2N3
MW: 276.919
Storage: 2-8 degree Celsius
SMILES: BrC=1C=NN2C1N=CC(=C2)Br
3,6-dibromopyrazolo[1,5-a]pyrimidine; CAS No.: 55405-68-0; 3,6-dibromopyrazolo[1,5-a]pyrimidine. PROPERTIES: 3,6-dibromopyrazolo[1,5-a]pyrimidine is a white crystalline powder with molecular formula C7H4Br2N4. It has a molar mass of 311.93 g/mol and shows limited water solubility but good solubility in dimethylformamide and dimethyl sulfoxide. The compound melts between 185-188 C. Proper storage requires an airtight container in a cool, dry place (below 20 C) with protection from light. Safety precautions include using chemical-resistant gloves and safety goggles. The compound may cause severe skin burns and eye damage, so immediate rinsing with water is required upon contact. If swallowed, medical attention should be sought immediately. The material should be stored away from heat and incompatible substances like amines. APPLICATIONS: In pharmaceutical development, 3,6-dibromopyrazolo[1,5-a]pyrimidine is used as a building block for creating kinase inhibitors. Research groups focusing on cancer therapy have utilized this compound to develop inhibitors targeting the Aurora kinase family. The bromine substituents provide functionalities for forming coordination complexes with metal ions in the kinase active site. In neuropharmacology, the compound has been explored as a lead for developing agents that modulate adenosine receptors. A study published in a medicinal chemistry journal demonstrated how derivatives of 3,6-dibromopyrazolo[1,5-a]pyrimidine exhibited anxiolytic effects in rodent models of anxiety. Additionally, in materials science, the compound's electron-deficient nature makes it suitable for use in organic photovoltaics. Researchers at a renewable energy laboratory incorporated 3,6-dibromopyrazolo[1,5-a]pyrimidine derivatives into donor-acceptor architectures to improve power conversion efficiencies in small-molecule solar cells.
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