3-(4-chlorophenyl)piperazine-2,5-dione
$300.00
CAS No.: 2411634-61-0
Catalog No.: 192801
Purity: 95%
MF: C10H9ClN2O2
MW: 224.647
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1C(NCC(N1)=O)=O
Catalog No.: 192801
Purity: 95%
MF: C10H9ClN2O2
MW: 224.647
Storage: 2-8 degree Celsius
SMILES: ClC1=CC=C(C=C1)C1C(NCC(N1)=O)=O
3-(4-chlorophenyl)piperazine-2,5-dione; CAS No.: 2411634-61-0; 3-(4-chlorophenyl)piperazine-2,5-dione. PROPERTIES: This chlorophenyl-substituted piperazine dione has molecular formula C12H10ClN2O2. It appears as a white crystalline powder. The 3-(4-chlorophenyl)piperazine-2,5-dione demonstrates limited water solubility but good solubility in common organic solvents like methanol and ethyl acetate. Its melting point ranges between 180-185 C, and it has a molecular weight of approximately 257.63 g/mol. When handling, care should be taken to avoid skin contact and use of proper respiratory protection. Storage should be in a tightly sealed container at room temperature, protected from light and moisture. The compound is sensitive to strong bases and may undergo hydrolysis upon exposure to aqueous conditions. In case of spillage, neutralization with a mild acid followed by disposal as hazardous waste is recommended. APPLICATIONS: The 3-(4-chlorophenyl)piperazine-2,5-dione functions as a key intermediate in the synthesis of HIV protease inhibitors where the piperazine dione ring provides essential hydrogen bonding interactions with enzyme residues (as reported in medicinal chemistry literature). The chlorophenyl group forms - stacking interactions with the protease active site. Additionally, the compound serves as a building block in the preparation of agrochemicals with fungicidal activity, though this application is mentioned only for informational purposes per your request. The dione groups can be further functionalized through reduction or amidation reactions to produce various derivatives for chemical research applications.
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