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3-(4-chlorobutyl)indole-5-carbonitrile; CAS No.: 143612-79-7; This chlorobutyl indole nitrile demonstrates our building blocks for drug discovery in melatonin receptor research. The 5-cyano group enhances binding affinity while the 4-chlorobutyl chain improves metabolic stability. Our Fischer indole synthesis protocol achieves regioselective cyclization, supporting development of circadian rhythm regulators with extended half-lives.