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(2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid; CAS No.: 618-27-9; As a chemical online mall, ChemShuttle offers (2S,4S)-4-hydroxypyrrolidine-2-carboxylic acid for constrained peptide design. This bicyclic amino acid derivative imposes structural rigidity through its trans-dihydroxypyrrolidine ring system. The compound's molecular weight 131.13 and calculated PSA 87 ?2 enhance water solubility for biological applications. Our custom synthesis companies employ asymmetric catalysis to achieve >99% diastereomeric purity. The hydroxyl groups enable hydrogen bonding interactions while the carboxylic acid allows peptide coupling. We provide guidance on Fmoc protection strategies and support solid-phase peptide synthesis applications. Technical documents include circular dichroism spectra and solubility profiles in various buffers.