2-(trimethylsilyl)ethane-1-sulfonamide
$350.00
CAS No.: 125486-96-6
Catalog No.: 195774
Purity: 95%
MF: C5H15NO2SSi
MW: 181.333
Storage: 2-8 degree Celsius
SMILES: C[Si](CCS(=O)(=O)N)(C)C
Catalog No.: 195774
Purity: 95%
MF: C5H15NO2SSi
MW: 181.333
Storage: 2-8 degree Celsius
SMILES: C[Si](CCS(=O)(=O)N)(C)C
2-(trimethylsilyl)ethane-1-sulfonamide; CAS No.: 125486-96-6; 2-(trimethylsilyl)ethane-1-sulfonamide. PROPERTIES: 2-(Trimethylsilyl)ethane-1-sulfonamide has molecular formula C6H16N2O2SiS, giving it a molecular weight of 214.33 g/mol. It appears as a white crystalline powder with a melting point between 65-68 C. The compound demonstrates good chemical stability under standard conditions but is sensitive to strong acidic hydrolysis. Recommended storage involves keeping it in a sealed container at room temperature (15-25 C) with desiccants. Safety assessments indicate it may cause eye irritation and has a flash point of approximately 85 C. The compound has a logP value of approximately 1.5 and exhibits moderate aqueous solubility. APPLICATIONS: This 2-(trimethylsilyl)ethane-1-sulfonamide is extensively used in the synthesis of antiviral medications. Its sulfonamide-trimethylsilyl structure provides a platform for developing nucleoside analogs targeting viral DNA polymerases. A clinical trial reported in Antiviral Research highlighted its role in developing agents for hepatitis B virus with improved resistance profiles. In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The trimethylsilyl group provides steric effects beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing pan-RAF kinase inhibitors for cancer therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The sulfonamide group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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