2-methyl-2H-indazole-7-carbaldehyde
$350.00
CAS No.: 1337880-42-8
Catalog No.: 195535
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: CN1N=C2C(=CC=CC2=C1)C=O
Catalog No.: 195535
Purity: 95%
MF: C9H8N2O
MW: 160.176
Storage: 2-8 degree Celsius
SMILES: CN1N=C2C(=CC=CC2=C1)C=O
2-methyl-2H-indazole-7-carbaldehyde; CAS No.: 1337880-42-8; 2-methyl-2H-indazole-7-carbaldehyde. PROPERTIES: 2-methyl-2H-indazole-7-carbaldehyde is a white to off-white crystalline solid with molecular formula C10H7N3O. It exhibits a melting point of approximately 175-178 C and moderate thermal stability. The compound shows good solubility in polar aprotic solvents like acetonitrile and moderate solubility in methanol. Recommended storage conditions include maintaining temperatures below 25 C in sealed containers. Safety precautions involve using particle-filtering half masks during handling to prevent inhalation of dust and wearing lab coats to protect clothing from contamination. APPLICATIONS: This indazole aldehyde derivative serves as a key intermediate in the synthesis of dual PI3K/mTOR inhibitors, where the 2-methyl-2H-indazole-7-carbaldehyde group participates in hydrogen bonding interactions with kinase domains (Medicinal Research Reviews). In chemical biology, the compound is used as a warhead for developing covalent inhibitors targeting protein-protein interaction interfaces (ACS Chemical Biology). Additionally, its carbonyl group enables convenient reductive amination reactions for the preparation of diverse amine-containing libraries in high-throughput screening campaigns (Journal of Combinatorial Chemistry).
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