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2-methyl-2,7-diazaspiro[3.5]nonane dihydrochloride
$332.00
CAS No.: 1610028-42-6
Catalog No.: 195839
Purity: 95%
MF: C8H18Cl2N2
MW: 213.152
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN1CC2(C1)CCNCC2
Catalog No.: 195839
Purity: 95%
MF: C8H18Cl2N2
MW: 213.152
Storage: 2-8 degree Celsius
SMILES: Cl.Cl.CN1CC2(C1)CCNCC2
2-methyl-2,7-diazaspiro[3.5]nonane dihydrochloride; CAS No.: 1610028-42-6; 2-methyl-2,7-diazaspiro[3.5]nonane dihydrochloride. PROPERTIES: 2-Methyl-2,7-diazaspiro[3.5]nonane dihydrochloride has molecular formula C8H16N2 {2HCl, giving it a molecular weight of 212.14 g/mol. It appears as a white crystalline powder with a melting point between 195-198 C. The compound demonstrates good chemical stability under standard conditions but is hygroscopic. Recommended storage involves keeping it in a tightly sealed container at room temperature (15-25 C) with desiccants. Safety data indicates it may cause respiratory irritation and requires use of chemical splash goggles and lab coats during handling. The compound has a logP value of approximately 0.9 and exhibits high aqueous solubility. APPLICATIONS: This 2-methyl-2,7-diazaspiro[3.5]nonane dihydrochloride is extensively used in the synthesis of antimicrobial agents. Its diazaspiro structure provides a platform for developing antibacterial agents targeting bacterial dihydrofolate reductase. A study in Antimicrobial Agents and Chemotherapy highlighted its role in creating antibacterial agents with activity against methicillin-resistant Staphylococcus aureus (MRSA). In pharmaceutical applications, it serves as a building block for synthesizing kinase inhibitors. The diazaspiro group provides hydrogen-bonding interactions beneficial for optimizing kinase hinge binding. Research in the Journal of Medicinal Chemistry demonstrated its utility in developing JAK3 inhibitors for autoimmune disease therapy. Additionally, the compound is utilized in the preparation of fluorescent probes. The diazaspiro group provides a site for installing fluorescence tags, enabling detection of enzymatic activity in biological systems, as reported in Bioconjugate Chemistry.
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