(2-methoxyphenyl)(piperazin-1-yl)methanone
$360.00
CAS No.: 100939-88-6
Catalog No.: GS3268
Purity: 95%
MF: C12H16N2O2
MW: 220.272
Storage: 2-8 degree Celsius
SMILES: COC1=C(C=CC=C1)C(=O)N1CCNCC1
Catalog No.: GS3268
Purity: 95%
MF: C12H16N2O2
MW: 220.272
Storage: 2-8 degree Celsius
SMILES: COC1=C(C=CC=C1)C(=O)N1CCNCC1
CAS NO.: 100939-88-6;(2-methoxyphenyl)(piperazin-1-yl)methanone. PROPERTIES: This methoxyphenyl piperazine derivative presents as a white crystalline solid with a molecular weight of approximately 249.3 g/mol. The (2-methoxyphenyl)(piperazin-1-yl)methanone combines a methoxyphenyl group with a piperazine ring and a ketone functionality. It exhibits moderate solubility in water and good dissolution in lower alcohols and ketones. Stability characterization reveals vulnerability to oxidation and base-catalyzed hydrolysis of the ketone group, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The (2-methoxyphenyl)(piperazin-1-yl)methanone serves as a key intermediate in the synthesis of various pharmaceuticals. Its methoxyphenyl group provides enhanced solubility in lipid phases compared to non-methoxy analogs. Research teams utilize this compound as a starting material for creating serotonin receptor modulators and antipsychotic agents. The ketone group undergoes reduction to form secondary alcohols for further functionalization. Additionally, it serves as a building block for creating GABA receptor modulators with enhanced subtype selectivity. The compound's unique substitution pattern makes it valuable in the development of kinase inhibitors and ion channel modulators.
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