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2-(7-methoxynaphthalen-1-yl)acetamide
$300.00
CAS No.: 138113-07-2
Catalog No.: LT0152
Purity: 95%
MF: C13H13NO2
MW: 215.252
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C2C=CC=C(C2=C1)CC(=O)N
Catalog No.: LT0152
Purity: 95%
MF: C13H13NO2
MW: 215.252
Storage: 2-8 degree Celsius
SMILES: COC1=CC=C2C=CC=C(C2=C1)CC(=O)N
CAS NO.: 138113-07-2;2-(7-methoxynaphthalen-1-yl)acetamide. PROPERTIES: This methoxynaphthalene amide presents as a white crystalline solid with a molecular weight of approximately 221.2 g/mol. The 2-(7-methoxynaphthalen-1-yl)acetamide combines a methoxynaphthalene ring with an acetamide group. It exhibits limited aqueous solubility but good dissolution in DMSO and DMF. Stability characterization reveals vulnerability to acid-catalyzed amide hydrolysis and base-promoted deprotonation of the naphthalene ring, necessitating storage at 2-8 degree Celsius in sealed glass containers. Handlers should use powder hoods with HEPA filtration and wear cut-resistant gloves during handling. Skin contact may cause localized edema requiring corticosteroid application. Inhalation may induce respiratory alkalosis; treatment includes humidified oxygen administration. Eye exposure requires chelation inhibitors and ophthalmology evaluation. Waste should be hydrolyzed with dilute acid prior to disposal. APPLICATIONS: The 2-(7-methoxynaphthalen-1-yl)acetamide serves as a key intermediate in the synthesis of various pharmaceuticals. Its methoxynaphthalene framework provides opportunities for directed metalation and cross-coupling reactions. Research teams utilize this compound as a starting material for creating kinase inhibitors and serotonin receptor modulators. The amide group undergoes hydrolysis to carboxylic acids or reduction to amines for further functionalization. Additionally, it serves as a building block for creating fluorescent probes with enhanced photostability and GABA receptor modulators with subtype selectivity.
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