2,3-difluoro-4-methylbenzoic acid
$300.00
CAS No.: 261763-37-5
Catalog No.: 197131
Purity: 95%
MF: C8H6F2O2
MW: 172.13
Storage: 2-8 degree Celsius
SMILES: FC1=C(C(=O)O)C=CC(=C1F)C
Catalog No.: 197131
Purity: 95%
MF: C8H6F2O2
MW: 172.13
Storage: 2-8 degree Celsius
SMILES: FC1=C(C(=O)O)C=CC(=C1F)C
2,3-difluoro-4-methylbenzoic acid; CAS No.: 261763-37-5; 2,3-difluoro-4-methylbenzoic acid. PROPERTIES: This difluoro-methyl-substituted benzoic acid features molecular formula C?H?F?O? with molecular weight 172.13 g/mol. It generally appears as a white crystalline powder. Soluble in polar protic solvents like methanol and water. Melting point approximately 130-135 C. Exhibits IR absorption for carboxylic acid (~2900-2500 cm??) and C-F groups (~1300-1100 cm??). Thermogravimetric analysis indicates decomposition above 180 C under nitrogen. For optimal stability, store at 2-8 C in tightly sealed containers with desiccant, protected from light. The compound may cause mild skin irritation and serious eye damage; therefore, standard laboratory safety precautions including protective clothing and eye protection are recommended during handling. APPLICATIONS: As a difluoro-methyl-substituted benzoic acid, 2,3-difluoro-4-methylbenzoic acid is predominantly utilized in the synthesis of kinase inhibitors. It serves as a key intermediate in constructing the core scaffold of these compounds, where the fluoro and methyl groups provide valuable binding affinity for the kinase active site as demonstrated in medicinal chemistry research (Journal of Medicinal Chemistry). Additionally, the compound participates in the development of fluorescent probes for bioimaging applications, where its carboxylic acid functionality enables conjugation to biomolecules via amide bond formation (Bioconjugate Chemistry). In materials science, it functions as a monomer for preparing polyurethane foams with enhanced thermal stability, where the fluoro substituents contribute to improved flame retardancy and mechanical properties (Polymer International).
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